Members of the Toll-like receptor–interleukin 1 receptor superfamily signal inflammatory responses. However, a member of this family is now shown to modulate these responses by acting as a negative regulator.
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References
Dunne, A. & O'Neill, L.A.J. Sci. STKE. 171, re3 (2003).
Wald, D. et al. Nat. Immunol. 4, 920–927 (2003).
Thomassen, E. et al. Cytokine 11, 389–399 (1999).
O'Neill, L.A. et al. Trends Immunol. 24, 286–290 (2003).
Yamamoto, M. et al. Science, 301, 640–643 (2003).
Hoebe, K. et al. Nature 424, 743–748 (2003).
Debets, R. et al. J. Immunol. 167, 1440–1446 (2001).
Dunn, E. et al. Trends Immunol. 22, 533–536 (2001).
Burns, K. et al. J. Exp. Med. 197, 263–268 (2003).
Kobayashi, K. et al. Cell 110, 191–202 (2002).
Kinjyo, I. et al. Immunity 17, 583–591 (2002).
Bartfai, T. et al. Proc. Natl. Acad. Sci. USA 100, 7971–7976 (2003).
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O'Neill, L. SIGIRR puts the brakes on Toll-like receptors. Nat Immunol 4, 823–824 (2003). https://doi.org/10.1038/ni0903-823
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DOI: https://doi.org/10.1038/ni0903-823
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